Cannabinoids and tinnitus?

We have written extensively on cannabinoids with apparent beneficial effects in a wide range of neurogenic disorders. These effects range so broadly as to include degenerative syndromes, cognitive impairments, and developmental disorders. 

Why not tinnitus, fundamentally a neurological matter? There is, as a matter of fact, evidence to suggest that tinnitus sufferers sometimes do self-medicate with cannabis. 

A study in New Zealand was undertaken recently to evaluate critically the available evidence relating to any possible effects of pharmaceutical cannabinoids on tinnitus(Zheng Y, Smith PF. Cannabinoid drugs: will they relieve or exacerbate tinnitus? Curr Opin Neurol. 2019 Feb;32(1):131-136. doi: 10.1097/WCO.0000000000000631). 

Cannabinoids have indeed been shown to decrease neuronal hyperactivity in parts of the brain. But unfortunately, what data there is currently suggests that in the auditory regions, notably the dorsal cochlear nucleus, cannabinoids may actually increase neuronal hyperactivity and exacerbate tinnitus. More broadly, all available evidence from animal studies suggests that CB1 receptor agonists, at least, should either have no effect on tinnitus or make it worse. 

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The foregoing is a report on trends and developments in the cannabinoid industry. No product described herein is intended to diagnose, treat, cure or prevent any disease or syndrome.